Canine Chromosome 9
Hypopituitary dwarfism is caused by the deletion of just 7 base pairs GCGCCCC on LHX3 at intron 5. If you look down at the bottom of the long arm of chromosome 9 (CFA9) below you can see the location. Although the image uses a human chromosome 9 the location for a German Shepherd is the same as a human. As there is no easy to read image for a dog at present, a highly specialised technical link is given however to the relevant site for CFA9 LHX3 at the Canine Genome project:
http://www.ncbi.nlm.nih.gov/gene/607584
Hypopituitary dwarfism is caused by the deletion of just 7 base pairs GCGCCCC on LHX3 at intron 5. If you look down at the bottom of the long arm of chromosome 9 (CFA9) below you can see the location. Although the image uses a human chromosome 9 the location for a German Shepherd is the same as a human. As there is no easy to read image for a dog at present, a highly specialised technical link is given however to the relevant site for CFA9 LHX3 at the Canine Genome project:
http://www.ncbi.nlm.nih.gov/gene/607584
The precise location is 9q34.3 and is located from base pair 136,196,249 to 136,205,108 which can be seen on the diagram below:
LHX3
